The Hornets left North London empty handed on Saturday afternoon, an in-form Tottenham side proving too much for the Golden Boys as Mauricio Pochettino ran out 4-0 winners at White Hart Lane.
Three first-half strikes from Dele Alli, Eric Dier and Heung-Min Son saw the hosts go into the break with a comfortable lead.
A further goal in the second-half from Son ensured Pochettino’s team secured all three points to maintain their position in second place.
It was a much changed Hornets line-up from that which defeated West Brom on Tuesday night.
Etienne Capoue and Troy Deeney made the bench, Miguel Britos was suspended and Sebastian Prödl injured.
Adrian Mariappa started at the heart of the defence following his impressive performance against the Baggies, and there were recalls for Daryl Janmaat and Stefano Okaka.
Isaac Success was in the starting side for his first game since Middlesbrough away in October.
The Hornets created the first opportunity of the match as Jose Holebas was fouled on the edge of the box by Alli. The wide-man stepped up to take, but saw his curling effort saved by Hugo Lloris.
The hosts should have gone ahead through Janssen but the striker’s connection with Kieran Trippier's cross wasn't clean, the ball deflecting against the bar.
A moment of magic saw Spurs on their way. A quick break allowed Alli to collect the ball out on the left. The midfielder shifted it onto his right-foot and curled a spectacular effort into the corner past the dive of Gomes.
Six minutes later the lead was extended as a ball in found its way to Dier on the edge of the box. The England international made no mistake as he thrashed a powerful effort into the back of the net.
And a quick-fire third from Son on the stroke of half-time meant it would be an uphill battle for the Hornets. The South-Korean glided centrally and stroked a left-footed shot into the bottom corner from outside the box.
Full-back Janmaat tried his luck early into the second-half however his left-footed effort bounced wide of the far-post.
Spurs notched a fourth and final goal shortly after. Trippier’s ball to the far post was met by Son as he coolly slotted in first-time on the volley for his second of the match.
The Hornets were inches away from scoring a consolation, but Success dragged his shot wide of the far-post, following an impressive back heel from Okaka to play him in.
The front-man had a good chance as he took down Holebas’ clip into the box, but his shot with the outside of his foot drifted wide.
As the game neared an end, Son missed two good chances to complete his hat-trick. He first put wide at the far post and then scraped the top of the bar with a well-struck volley.
The final substitution for the Hornets came with five minutes left to play as Okaka was replaced by the returning Christian Kabesele.
With the last kick of the game Kane rattled the bar with a finely-struck free-kick, the final act of a difficult afternoon for the Hornets.
HORNETS: Gomes (GK) (c); Mariappa, Cathcart, Holebas; Janmaat, Cleverley, Doucouré (Zúñiga, 59), Amrabat (Deeney, 69); Niang, Okaka (Kabasele, 84), Success.
Subs not used: Pantilimon (GK), Eleftheriou, Mason, Capoue.
Yellow cards: Doucouré (33)
SPURS: Lloris (c); Trippier, Alderweireld, Vertonghen, Davies; Dier, Dembele (Sissoko, 74); Alli, Eriksen, Son (Onomah, 88); Janssen (Kane, 60).
Subs not used: Lopez (GK), Walker, Nkoudou, Wimmer.
Goals: Alli (33), Dier (39), Son (44, 55)
Referee: Anthony Taylor